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norskBlar i forfatter "Norvik, Jon Viljar"
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Antibiotikaforeskrivning hos norske allmennpraktikere: en kvalitativ studie
(Master thesis; Mastergradsoppgave, 2009-10-01)Norges allmennpraktikere er restriktive i sin antibiotikaforeskrivning. Denne studien ser på årsaken til deres restriktive holdning ved hjelp av den kvalitative metode. Studien baserer seg på intervjuer av sju norske allmennleger som er transkriberte og analyserte. Det blir vist at en restriktiv holdning til antibiotika blir sett på som en positiv verdi blant allmennpraktikerne, og den eneste faktoren ... -
Assessment of otoscopy: how does observation compare to a review of clinical evidence?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015)Background and Purpose: To investigate how much the method of observation agrees with a standardised review of evidence of clinical examination, for the assessment of clinical otoscopic competence. <br> Methods: 65 medical students took part in an Objective Structured Clinical Examination (OSCE) station using patients with real pathology. Examiners assessed otoscopic competency in tympanic membrane ... -
The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-14)Background/Aims: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponectin, serum uric acid (SUA) and urinary biomarkers of glomerular and tubular damage (albumin-creatinine ... -
Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-18)<i>Introduction</i> - Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used ... -
Associations of urinary orosomucoid, N-acetyl-β-D-glucosaminidase, and albumin with blood pressure and hypertension during 7 years of follow-up. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-03)Purpose: Subclinical chronic kidney disease is known to exacerbate hypertension and progression of kidney damage. In order to initiate timely interventions, early biomarkers for this vicious circle are needed. Our aim was to describe the cross-sectional associations of urinary orosomucoid and urinary N-acetyl-b-D-glucosaminidase (NAG) with blood pressure and the longitudinal associations of urinary ... -
Correlation between baseline GFR and subsequent change in GFR in Norwegian adults without diabetes and in Pima Indians
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-28)<p><i>Rationale & Objective - </i>An elevated glomerular filtration rate (GFR), or renal hyperfiltration, may predispose individuals to subsequent rapid GFR decline in diabetes, obesity, and metabolic syndrome. Although this hypothesis is supported by results of experimental studies, the importance of hyperfiltration at the population level remains controversial. We investigated whether higher ... -
Gender differences in hearts subjected to decreased NO-production and elevated blood pressure
(Master thesis; Mastergradsoppgave, 2016-10-31)Hypertension is one of the most important risk factors for heart failure in the general population. Hypertensive heart failure is associated with heart failure with preserved ejection fraction (HFpEF). Women have an increase proportion of HFpEF compared to men. Endothelial dysfunction thereby reduced NO production is proposed to play an important role in the pathophysiology of HFpEF. A suggested ... -
Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-14)Uric acid is a purine degradation product but also an important antioxidant and ROS scavenger. Experimental settings that mimic myocardial ischemia-reperfusion have not included uric acid despite that it is always present in human extracellular fluid and plasma. We hypothesized that uric acid has an important role in myocardial ROS scavenging. Here, we tested the cardiac response to uric acid on ... -
Low adiponectin is associated with diastolic dysfunction in women: A cross-sectional study from the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-14)Background: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. <br>Methods: We conducted a cross-sectional ... -
Mild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)<i>Introduction</i>: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, ... -
Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)Background: Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS). In a prospective cohort study, we assessed whether baseline and longitudinal change in UA were risk factors for development of MetS and its individual components. <br> Methods: We included 3087 women and 2996 men who had UA measured in the population based Tromsø Study 1994–95. The participants ... -
Serum Matrix Metalloproteinase 7 and accelerated glomerular filtration rate decline in a general non-diabetic population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-26)Background. Age-related reduction of glomerular filtration rate (GFR) is a major contributor to the global chronic kidney disease (CKD) epidemic. We investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP1), which mediates fibrosis development in aging animals, were associated with ... -
Sex Differences in Age-Related Loss of Kidney Function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-30)Background - CKD is more prevalent in women, but more men receive kidney replacement therapy for kidney failure. This apparent contradiction is not well understood.<p> <p>Methods - We investigated sex differences in the loss of kidney function and whether any sex disparities could be explained by comorbidity or CKD risk factors. In the Renal Iohexol Clearance Survey (RENIS) in northern Europe, ... -
Uric acid and adiponectin in cardiovascular disease
(Doctoral thesis; Doktorgradsavhandling, 2017-04-20)Uric acid, a product of metabolism, was discovered a quarter of a millennium ago and has been known to be a possible cardiovascular risk factor for well over a century. A much newer discovery, adiponectin, was discovered only a little more than 20 years ago as a protein hormone secreted by adipose tissue and has attracted substantial attention for its association with cardiovascular disease. This ... -
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional ... -
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-11)Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline ... -
Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994-2013
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-31)Aims: To investigate whether serum uric acid predicts adverse outcomes in persons with indices of diastolic dysfunction in a general population. <br>Methods and results: We performed a prospective cohort study among 1460 women and 1480 men from 1994 to 2013. End- points were all-cause mortality, incident myocardial infarction, and incident ischaemic stroke. We strati fi ed the analyses ... -
Urinary excretion of epidermal growth factor and rapid loss of kidney function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-17)Background - Lower urinary excretion of the kidney tubule–specific biomarker epidermal growth factor (uEGF) is associated with increased risk of renal function [glomerular filtration rate (GFR)] loss in diabetes and in patients with established chronic kidney disease (CKD). We investigated whether uEGF is associated with rapid GFR decline or incident CKD in the general population.<p> <p>Methods ...
